Even though they’re technically playing coy, there are a lot of hints that Indiana Jones’ next adventure will involve an encounter with aliens. (See io9 for a major hint–and semi-spoiler–in this direction.)
Sounds enough like SF to be blogged about here. :)
The Indiana Jones site has the first trailer (which includes a glimpse of a package bound for Roswell, NM), along with a bunch of short featurettes about the making of the film.
Link (Hat tip to Professor Fate)